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From I-90 (the Thruway) take Exit 48-A (Medina/Pembroke). Turn left (north) onto Route 77 towards Medina and Indian Falls. Go approximately 8 miles. At the flashing traffic light in Alabama, go straight for one more mile. Turn left onto Casey Road. There will be a green and white sign for Iroquois National Wildlife Refuge Headquarters at the intersection. Refuge headquarters is one mile on the right.